Effective suppression of azoxymethane‐induced aberrant crypt foci formation in mice with citrus peel flavonoids
Identifieur interne : 001065 ( Main/Exploration ); précédent : 001064; suivant : 001066Effective suppression of azoxymethane‐induced aberrant crypt foci formation in mice with citrus peel flavonoids
Auteurs : Ching-Shu Lai [Taïwan] ; Shiming Li [États-Unis] ; Cheng Bin Liu [Taïwan] ; Yutaka Miyauchi [Japon] ; Michiko Suzawa [Japon] ; Chi-Tang Ho [États-Unis] ; Min-Hsiung Pan [Taïwan]Source :
- Molecular Nutrition & Food Research [ 1613-4125 ] ; 2013-03.
Abstract
Citrus peel or its extract has been reported to exhibit a broad spectrum of biological activity. Herein, we report the first investigation of inhibitory effects of a formulated product from citrus peel extract, gold lotion (GL), on azoxymethane‐induced colonic tumorigenesis. We have demonstrated that oral feeding of GL decreased the number of aberrant crypt foci (ACF), particularly large size of ACF in colonic tissues of mice. Both gene and protein expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase‐2 (COX‐2) were suppressed by GL treatment. The in vivo data have revealed for the first time that the citrus peel extract–GL–is an effective antitumor agent mechanistically downregulating the protein levels of iNOS, COX‐2, ornithine decarboxylase, vascular endothelial growth factor, and matrix metallopeptidase 9 in colonic tissues of mice, suggesting that GL is a novel functional natural product capable of preventing inflammation‐associated colon tumorigenesis.
Url:
DOI: 10.1002/mnfr.201200606
Affiliations:
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xml:lang="fr" wicri:curation="lc">Taïwan</country><wicri:regionArea>Dr. Min‐Hsiung Pan, Department of Seafood Science, National Kaohsiung Marine University, No.142, Haijhuan Road, Nanzih District, Kaohsiung 81143</wicri:regionArea><wicri:noRegion>Kaohsiung 81143</wicri:noRegion></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Taïwan</country></affiliation></author></analytic><monogr></monogr><series><title level="j">Molecular Nutrition & Food Research</title><title level="j" type="abbrev">Mol. 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Herein, we report the first investigation of inhibitory effects of a formulated product from citrus peel extract, gold lotion (GL), on azoxymethane‐induced colonic tumorigenesis. We have demonstrated that oral feeding of GL decreased the number of aberrant crypt foci (ACF), particularly large size of ACF in colonic tissues of mice. Both gene and protein expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase‐2 (COX‐2) were suppressed by GL treatment. The in vivo data have revealed for the first time that the citrus peel extract–GL–is an effective antitumor agent mechanistically downregulating the protein levels of iNOS, COX‐2, ornithine decarboxylase, vascular endothelial growth factor, and matrix metallopeptidase 9 in colonic tissues of mice, suggesting that GL is a novel functional natural product capable of preventing inflammation‐associated colon tumorigenesis.</div></front></TEI><affiliations><list><country><li>Japon</li><li>Taïwan</li><li>États-Unis</li></country><region><li>New Jersey</li></region><settlement><li>New Brunswick (New Jersey)</li></settlement><orgName><li>Université Rutgers</li></orgName></list><tree><country name="Taïwan"><noRegion><name sortKey="Lai, Ching Hu" sort="Lai, Ching Hu" uniqKey="Lai C" first="Ching-Shu" last="Lai">Ching-Shu Lai</name></noRegion><name sortKey="Liu, Cheng Bin" sort="Liu, Cheng Bin" uniqKey="Liu C" first="Cheng Bin" last="Liu">Cheng Bin Liu</name><name sortKey="Pan, Min Siung" sort="Pan, Min Siung" uniqKey="Pan M" first="Min-Hsiung" last="Pan">Min-Hsiung Pan</name><name sortKey="Pan, Min Siung" sort="Pan, Min Siung" uniqKey="Pan M" first="Min-Hsiung" last="Pan">Min-Hsiung Pan</name><name sortKey="Pan, Min Siung" sort="Pan, Min Siung" uniqKey="Pan M" first="Min-Hsiung" last="Pan">Min-Hsiung Pan</name></country><country name="États-Unis"><region name="New Jersey"><name sortKey="Li, Shiming" sort="Li, Shiming" uniqKey="Li S" first="Shiming" last="Li">Shiming Li</name></region><name sortKey="Ho, Chi Ang" sort="Ho, Chi Ang" uniqKey="Ho C" first="Chi-Tang" last="Ho">Chi-Tang Ho</name></country><country name="Japon"><noRegion><name sortKey="Miyauchi, Yutaka" sort="Miyauchi, Yutaka" uniqKey="Miyauchi Y" first="Yutaka" last="Miyauchi">Yutaka Miyauchi</name></noRegion><name sortKey="Suzawa, Michiko" sort="Suzawa, Michiko" uniqKey="Suzawa M" first="Michiko" last="Suzawa">Michiko Suzawa</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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